用作制药的原(yuan)料及有机中(zhong)间(jian)体，也可作溶剂(ji);用作分析试剂(ji)及钨、钼中(zhong)铝的萃(cui)取(qu)剂(ji);戊二酮又称乙酰(xian)丙酮，是杀菌(jun)剂(ji)甲基嘧菌(jun)胺、嘧菌(jun)胺和除草剂(ji)嘧磺隆的中(zhong)间(jian)体。;乙酰(xian)丙酮是有机合成中(zhong)间(jian)体，与胍生成氨..

可(ke)(ke)采(cai)用(yong)(yong)不(bu)同(tong)的(de)(de)(de)(de)(de)(de)工艺路线：丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)与(yu)(yu)(yu)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)烯(xi)(xi)(xi)(xi)酮(tong)(tong)(tong)(tong)(tong)(tong)反应(ying)或(huo)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酐(gan)与(yu)(yu)(yu)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)缩合或(huo)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)与(yu)(yu)(yu)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酯(zhi)(zhi)缩合。丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)与(yu)(yu)(yu)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)烯(xi)(xi)(xi)(xi)酮(tong)(tong)(tong)(tong)(tong)(tong)的(de)(de)(de)(de)(de)(de)反应(ying)的(de)(de)(de)(de)(de)(de)过程，实际上(shang)(shang)(shang)是(shi)以(yi)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)为原料，经(jing)(jing)(jing)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)烯(xi)(xi)(xi)(xi)酮(tong)(tong)(tong)(tong)(tong)(tong)、乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)异丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)烯(xi)(xi)(xi)(xi)酯(zhi)(zhi)，再(zai)经(jing)(jing)(jing)转化(hua)(hua)(hua)(hua)而得乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酰(xian)(xian)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)工艺过程如下(xia)(xia)：将(jiang)(jiang)含(han)有1/1000二硫(liu)化(hua)(hua)(hua)(hua)碳(tan)(tan)的(de)(de)(de)(de)(de)(de)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)气(qi)化(hua)(hua)(hua)(hua)后引入(ru)(ru)(ru)780-800℃的(de)(de)(de)(de)(de)(de)裂(lie)化(hua)(hua)(hua)(hua)炉，使之生(sheng)(sheng)成(cheng)(cheng)(cheng)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)烯(xi)(xi)(xi)(xi)酮(tong)(tong)(tong)(tong)(tong)(tong)(或(huo)冰醋酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)经(jing)(jing)(jing)气(qi)化(hua)(hua)(hua)(hua)磷酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)三乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酯(zhi)(zhi)催化(hua)(hua)(hua)(hua)剂(ji)存在(zai)(zai)下(xia)(xia)，以(yi)氨(an)(an)为稳定(ding)剂(ji)，经(jing)(jing)(jing)700℃裂(lie)化(hua)(hua)(hua)(hua)炉裂(lie)解(jie)为乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)烯(xi)(xi)(xi)(xi)酮(tong)(tong)(tong)(tong)(tong)(tong))，乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)烯(xi)(xi)(xi)(xi)酮(tong)(tong)(tong)(tong)(tong)(tong)用(yong)(yong)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)吸收(shou)，在(zai)(zai)硫(liu)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)或(huo)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酰(xian)(xian)磺酰(xian)(xian)存在(zai)(zai)下(xia)(xia)，于61-71℃使之与(yu)(yu)(yu)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)反应(ying)生(sheng)(sheng)成(cheng)(cheng)(cheng)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)异丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)烯(xi)(xi)(xi)(xi)酯(zhi)(zhi)，经(jing)(jing)(jing)分(fen)(fen)(fen)馏(liu)提纯(chun)后，乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)异丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)稀酯(zhi)(zhi)纯(chun)度可(ke)(ke)达93-95以(yi)上(shang)(shang)(shang)。再(zai)将(jiang)(jiang)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)异丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)烯(xi)(xi)(xi)(xi)酯(zhi)(zhi)气(qi)化(hua)(hua)(hua)(hua)，引入(ru)(ru)(ru)预热至560-570℃转化(hua)(hua)(hua)(hua)炉，经(jing)(jing)(jing)分(fen)(fen)(fen)子(zi)重(zhong)排生(sheng)(sheng)成(cheng)(cheng)(cheng)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酰(xian)(xian)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)，经(jing)(jing)(jing)冷(leng)(leng)凝，分(fen)(fen)(fen)馏(liu)提纯(chun)得成(cheng)(cheng)(cheng)品(pin)。每吨产(chan)品(pin)消耗丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)约(yue)2700kg。丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)与(yu)(yu)(yu)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酯(zhi)(zhi)缩合的(de)(de)(de)(de)(de)(de)过程是(shi)在(zai)(zai)金(jin)属钠存在(zai)(zai)下(xia)(xia)进行的(de)(de)(de)(de)(de)(de)。操作示例1在(zai)(zai)冷(leng)(leng)却(que)(que)的(de)(de)(de)(de)(de)(de)烧杯中(zhong)加(jia)(jia)(jia)入(ru)(ru)(ru)120ml精制(zhi)的(de)(de)(de)(de)(de)(de)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酯(zhi)(zhi)和32ml氨(an)(an)气(qi)。在(zai)(zai)氨(an)(an)基(ji)钠加(jia)(jia)(jia)完(wan)后,在(zai)(zai)冰水中(zhong)不(bu)停(ting)振摇(yao)24h后,在(zai)(zai)室(shi)温下(xia)(xia)放(fang)(fang)置(zhi)过夜。次日加(jia)(jia)(jia)入(ru)(ru)(ru)100g冰，继而加(jia)(jia)(jia)入(ru)(ru)(ru)同(tong)量(liang)的(de)(de)(de)(de)(de)(de)冰水，取其(qi)水层(ceng)(ceng)(ceng)，加(jia)(jia)(jia)入(ru)(ru)(ru)稀硫(liu)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)使呈酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)性。在(zai)(zai)此溶(rong)液(ye)(ye)中(zhong)加(jia)(jia)(jia)入(ru)(ru)(ru)饱和乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)铜(tong)(tong)溶(rong)液(ye)(ye)(将(jiang)(jiang)40g粉末(mo)状乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)铜(tong)(tong)加(jia)(jia)(jia)一(yi)定(ding)量(liang)的(de)(de)(de)(de)(de)(de)热水溶(rong)解(jie)而成(cheng)(cheng)(cheng)),使乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酰(xian)(xian)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)形成(cheng)(cheng)(cheng)铜(tong)(tong)盐(yan)析(xi)出。如反应(ying)液(ye)(ye)为碱性,可(ke)(ke)加(jia)(jia)(jia)入(ru)(ru)(ru)少量(liang)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)。过2-3h后，将(jiang)(jiang)青灰色乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酰(xian)(xian)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)抽滤(lv)(lv)，用(yong)(yong)水洗涤两次，直接移(yi)入(ru)(ru)(ru)分(fen)(fen)(fen)液(ye)(ye)漏斗中(zhong),加(jia)(jia)(jia)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)醚(mi)(mi)(mi)不(bu)断(duan)振摇(yao),同(tong)时加(jia)(jia)(jia)入(ru)(ru)(ru)50ml4N硫(liu)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)使其(qi)分(fen)(fen)(fen)解(jie)。取乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)醚(mi)(mi)(mi)溶(rong)液(ye)(ye),再(zai)用(yong)(yong)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)醚(mi)(mi)(mi)萃取酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)层(ceng)(ceng)(ceng)中(zhong)的(de)(de)(de)(de)(de)(de)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酰(xian)(xian)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong),合并两次乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)醚(mi)(mi)(mi)溶(rong)液(ye)(ye)，用(yong)(yong)氯化(hua)(hua)(hua)(hua)钙干燥。将(jiang)(jiang)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)醚(mi)(mi)(mi)蒸(zheng)去残留物继续(xu)蒸(zheng)馏(liu)，收(shou)集125-140℃馏(liu)分(fen)(fen)(fen)。再(zai)于135-140℃精留，收(shou)量(liang)约(yue)15-20g。沸点139℃。操作示例2在(zai)(zai)1500ml圆底(di)烧瓶中(zhong)，加(jia)(jia)(jia)入(ru)(ru)(ru)金(jin)属钠25g及(ji)20ml乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)醚(mi)(mi)(mi)，再(zai)加(jia)(jia)(jia)入(ru)(ru)(ru)225ml用(yong)(yong)冷(leng)(leng)却(que)(que)剂(ji)冷(leng)(leng)却(que)(que)过的(de)(de)(de)(de)(de)(de)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酯(zhi)(zhi)。在(zai)(zai)冷(leng)(leng)却(que)(que)和不(bu)断(duan)搅拌下(xia)(xia)加(jia)(jia)(jia)73ml丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)。在(zai)(zai)室(shi)温放(fang)(fang)置(zhi)4h，加(jia)(jia)(jia)入(ru)(ru)(ru)400ml水，将(jiang)(jiang)水上(shang)(shang)(shang)层(ceng)(ceng)(ceng)的(de)(de)(de)(de)(de)(de)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酯(zhi)(zhi)分(fen)(fen)(fen)离,水层(ceng)(ceng)(ceng)用(yong)(yong)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)中(zhong)和,然(ran)后加(jia)(jia)(jia)入(ru)(ru)(ru)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)铜(tong)(tong)溶(rong)液(ye)(ye)(125g乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)铜(tong)(tong)溶(rong)于1500ml水)即(ji)生(sheng)(sheng)成(cheng)(cheng)(cheng)绿(lv)色的(de)(de)(de)(de)(de)(de)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酰(xian)(xian)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)螯(ao)合物。放(fang)(fang)置(zhi)2-3h后，沉(chen)淀完(wan)全(quan)，过滤(lv)(lv)。将(jiang)(jiang)沉(chen)淀悬浮于乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)醚(mi)(mi)(mi)中(zhong)，用(yong)(yong)50ml40稀硫(liu)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)振荡，乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)醚(mi)(mi)(mi)层(ceng)(ceng)(ceng)用(yong)(yong)氯化(hua)(hua)(hua)(hua)钙干燥。蒸(zheng)去乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)醚(mi)(mi)(mi)，把残留的(de)(de)(de)(de)(de)(de)油状分(fen)(fen)(fen)馏(liu)，收(shou)集124-140℃馏(liu)分(fen)(fen)(fen)，再(zai)分(fen)(fen)(fen)馏(liu),收(shou)集139-140℃馏(liu)分(fen)(fen)(fen)。乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酐(gan)和丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)的(de)(de)(de)(de)(de)(de)缩合反应(ying)是(shi)在(zai)(zai)三氟化(hua)(hua)(hua)(hua)硼(peng)催化(hua)(hua)(hua)(hua)下(xia)(xia)进行的(de)(de)(de)(de)(de)(de)此法收(shou)率(lv)较高(gao)。乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酰(xian)(xian)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)的(de)(de)(de)(de)(de)(de)精制(zhi)方(fang)法：将(jiang)(jiang)约(yue)20ml乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酰(xian)(xian)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)粗品(pin)溶(rong)于80ml苯(ben)(ben)中(zhong)，然(ran)后与(yu)(yu)(yu)等体(ti)积的(de)(de)(de)(de)(de)(de)蒸(zheng)馏(liu)水振荡3h。易溶(rong)于水的(de)(de)(de)(de)(de)(de)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)分(fen)(fen)(fen)配到水相(xiang)中(zhong)，而乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酰(xian)(xian)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)则(ze)易溶(rong)于苯(ben)(ben)中(zhong)。苯(ben)(ben)相(xiang)中(zhong)的(de)(de)(de)(de)(de)(de)乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酰(xian)(xian)丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)可(ke)(ke)直接应(ying)用(yong)(yong)，也(ye)可(ke)(ke)将(jiang)(jiang)苯(ben)(ben)蒸(zheng)馏(liu)除。原料消耗定(ding)额：丙(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)(bing)酮(tong)(tong)(tong)(tong)(tong)(tong)（工业品(pin)，含(han)水＜0.5）2553kg/t；发烟硫(liu)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)（以(yi)H2SO4计）12kg/t；乙(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)(yi)酐(gan)（95）19kg/t；二硫(liu)化(hua)(hua)(hua)(hua)碳(tan)(tan)（化(hua)(hua)(hua)(hua)学纯(chun)）6kg/t。